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This is followed by a more gradual decline in serum digoxin concentration, which is dependent upon digoxin elimination from the body.

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do not take a double dose of digoxin to make up for a missed one.

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pyrimidine analogs moderate some antineoplastic agents have been reported to decrease the absorption of digoxin tablets due to their adverse effects on the gi mucosa.

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digoxin clearance is 12 14 less in females than males and may need to be considered in dosing calculations.

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erythromycin and clarithromycin and possibly other macrolide antibiotics and tetracycline may increase digoxin-zori absorption in patients who inactivate digoxin-zori by bacterial metabolism in the lower intestine, so that digitalis intoxication may result see clinical.

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digoxin also decreases the refractory period of the atria and ventricles while increasing the sinoatrial and av nodes.

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