This is followed by a more gradual decline in serum digoxin concentration, which is dependent upon digoxin elimination from the body.
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erythromycin and clarithromycin and possibly other macrolide antibiotics and tetracycline may increase digoxin-zori absorption in patients who inactivate digoxin-zori by bacterial metabolism in the lower intestine, so that digitalis intoxication may result see clinical.
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digoxin also decreases the refractory period of the atria and ventricles while increasing the sinoatrial and av nodes.
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