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Chloramphenicol diffuses readily into milk, pleural and ascitic fluids and crosses the placenta attaining concentrations of about 75 of that of the maternal blood 36 and 44 . … Lire la suite

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The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic rare, unpredictable, and unrelated to dose and generally fatal. … Lire la suite